Image Credit: Blood clot forming over a wound. David Gregory & Debbie Marshall. Licence: Attribution 4.0 International (CC BY 4.0)
SKIN-ON-A-CHIP
Flow air or liquid through your model at your convenience
Add your own TEER sensing device
Keep ideal flow conditions on top of the microscope
Skin-on-a-chip pack setup
Our technology offers a versatile platform for creating skin-on-a-chip models that mimic the microenvironment of human skin and keep ideal conditions for long-term experimentation. Our technology enables the study of skin biology and drug responses with the flexibility of adding your preferred device and gathering data with the most relevant assay for you, be it TEER, microscopy, or biochemical.
The skin-on-a-chip pack includes:
- Flow controller
- Microfluidic flow sensor (eg. Galileo)
- Several falcon reservoirs
- Recirculation bridge
- Tubings and fittings
- Level sensors
- Microfluidic ChipShop Fluidic 480
- Software (Galileo user interface)
- User guide
Our skin-on-a-chip pack includes all the components needed to set up a skin model, including pumps, controllers, and software. We can advise you on the best chip in case you don’t have a defined one yet. We also offer technical support and training to help researchers start their experiments.
Check our automated cell culture platform for more details on an integrated approach!
A little more about the suggested chip: Fluidic 480
The fluidic 480 cross-flow membrane chip from Microfluidic ChipShop comprises two in- and outlet ports above and below the membrane that allow molecule transfer. Different pore sizes, materials, and chip geometries with more inlets are also available.
- Suitable for metabolic studies, cell co-culture, and organ-on-chip experiments
- Compartments divided by a permeable membrane
- Membrane pores from 8 to 0.2 µm
- Chip available in TOPAS or PS
- Interaction area of 36mm2
- Connectors: mini Luer
Other compatible chips include Fluidic 568 and Fluidic 846.
Compatibility of skin-on-a-chip pack
Our skin-on-a-chip Pack was designed to be compatible with commercially available or homemade chips (specific adaptors might be required) and the most common supernatant assays. If you have a particular chip or assay that is not listed, please contact us!
Chips
- Microfluidic ChipShop
- Homemade devices, PDMS, PMMA, etc.
- Ibidi
- Synvivo
- and more!
Assays
- TEER
- Immunochemistry analysis
- Toxicity assays
- Extracellular acidification rate
- and more!
Skin-on-a-chip applications
- Drug discovery and development: Our skin-on-a-chip model can test the efficacy and toxicity of new drugs or drug combinations for treating skin diseases such as psoriasis, eczema, and skin cancer. This could speed up the drug development and lead to more effective patient treatments.
- Personalized medicine: By using patient-derived cells and tissues in the model, it may be possible to develop customized treatment plans for patients with skin diseases. This could improve treatment outcomes and reduce side effects.
- Disease modeling: The model could be used to study the underlying mechanisms of skin diseases and to develop new hypotheses about the diseases. This could lead to new insights and discoveries that could ultimately improve our understanding of skin diseases and lead to new treatments.
- Preclinical testing: The skin-on-a-chip model could be used to test the safety and efficacy of new drugs before they are tested in humans. This could reduce the number of animals used in preclinical testing and improve drug testing accuracy.
- Cosmetics testing: Our skin-on-a-chip model could be used to test the safety and efficacy of cosmetic products, such as creams and lotions. This could reduce the need for animal testing and improve the accuracy of cosmetic testing.
We have recently published a review about the different organ-on-a-chip models and current innovations.
Customize your pack
We offer compatible instruments for standard commercialized chips from various brands. We can customize your pack to suit your specific needs with guidance from our specialists, who will suggest the best instruments and accessories. We’ll also help you set up the perfusion platform.
– Check our other Packs for various applications –
Can I order a pack?
Since Packs are products that are still being developed, we have a few eligibility criteria to maximize their success rate. A discussion with our experts is needed to determine your specific needs to offer you a personalized response.
Can the platform be sterilized/autoclaved?
Yes, we have developed a simple protocol for sterilization and cleaning that is provided along with the user guide.
Can a pack be customized based on my specific application?
Yes! Our experts will establish which instruments are best suited for your application, such as the type of flow sensor or the number of flow controller channels you need to perform your experiment. Contact us using the “talk to our experts” green button above.
Can I buy individual instruments?
Our instruments are in beta testing phase and can be tested as a pack or individually, so get in contact with our team to know how our beta testing program works.
Funding and Support
The ALTERNATIVE and LIFESAVER projects helped develop this pack.
These projects are funded by the European Union’s H2020-LC-GD-2020-3, grant agreements No. 101037090 (ALTERNATIVE) and 101036702 (LIFESAVER).
