Call SC1-BHC-11-2020 about animal-free chemical assessment now open!
Animal-free chemicals safety assessment: call SC1-BHC-11-2020
What we can do, as an SME partner:
For the call SC1-BHC-11-2020, we will mobilize our skills in microfluidic instrumentation and fluid handling to help you develop an organ-on-chip platform to assess the safety of chemicals. In particular, we can:
- Provide a solution for the perfusion of your organ-on-chip device
- Optimize the flow inside your organ-on-a-chip (thanks to programmed sequences, use of valves, etc.)
- Propose a user-friendly organ-on-chip platform to simplify the use of microfluidics as much as possible and make the technology accessible to non-specialists
What organ-on-chip can do for animal-free chemicals safety assessment
The use of organ-on-chip for the animal-free safety assessment of chemicals in the frame of a collaboration with an industrial partner is perfectly aligned with the expected impacts of the call SC1-BHC-11-2020:
- Scientifically sound, practicably implementable non-animal solutions readily deployable to aid in meaningful safety assessment of chemicals.
⇒ Organ-on-chip aims to recreate an organ, or part of an organ, at the microscale. The effect of chemicals on health can be studied in these model organs, which can even be connected.
- Uptake and commercial exploitation of the developed safety assessment approaches, products, and services.
⇒ Our focus will be on developing user-friendly and easy-to-use tools for organ-on-chip technology, with the clear objective of democratizing this technique for evaluating new molecules. As an industrial partner, we are experienced in developing innovative products aligned with the expectations of the end users, and we will help you design a tool suitable for commercialization.
- Contribution to the Three Rs (3Rs) principles (‘Replacement’, ‘Reduction’, ‘Refinement’), with a particular emphasis on the ‘Replacement’ opportunities.
⇒ Organ-on-chip allows us to model the natural body barriers in a much more physiologically relevant way than conventional cell culture (e.g., the possibility of inducing shear stress on cells to control the microenvironment of the cells very precisely). They offer a promising way to replace animal chemical and drug evaluation testing.
The MIC as an SME partner
The MIC already brought its microfluidics expertise into many research projects:
H2020-NMBP-TR-IND-2020
Microfluidic platform to study the interaction of cancer cells with lymphatic tissue
H2020-LC-GD-2020-3
Toxicology assessment of pharmaceutical products on a placenta-on-chip model
H2020-LC-GD-2020-3
Environmenal analysis using a heart-on-chip tissue model