Tips & Tricks for a successful HORIZON-HLTH-2026-03-DISEASE-13 proposal
Opening
10 February 2027
Deadline
Keywords
clinical networks
Global Health
Health Resilience
implementation research
Pandemic Preparedness
European clinical research
EU Health Programme
Your microfluidic SME partner for Horizon Europe
We take care of microfluidic engineering, work on valorization and optimize the proposal with you
HORIZON-HLTH-2026-03-DISEASE-13: European Partnership for Pandemic Preparedness (Phase 2)
This is not some ordinary open call for proposals. What the Commission is doing here is extending, and to an already established EU co-funded partnership, new activities and, possibly, new partners, under the existing grant agreement. The Commission’s short-term goal is a truly prepared Europe ready to deal with the next pandemic before it strikes. That is, clinical networks that remain active between crises, infrastructure that is genuinely cross-border, and a research ecosystem in which national funding agencies, the EU, and researchers co-operate (and not in parallel).
Download the MIC Horizon Europe 2026/2027 Calls Calendar:
Discover more!
Administrative facts: what do we know about the HORIZON-HLTH-2026-03-DISEASE-13 call?
- Call name: Partnerships in Health (2026/2)
- Call identifier: HORIZON-HLTH-2026-03
- Destination: Tackling diseases and reducing disease burden
- Topic: HORIZON-HLTH-2026-03-DISEASE-13: European Partnership for Pandemic Preparedness (Phase 2)
- Opening date: 10 February 2027
- Deadline: 13 April 2027 (17:00 Brussels local time)
- Type of action: Program Co-fund Action (COFUND)
- Total indicative budget: EUR 63.00 million (EUR 30.00 million in 2026 and EUR 33.00 million in 2027)
- Number of projects expected to be funded: 1
- Funding rate: 50% of eligible costs
- Critical eligibility restriction: the proposal must be submitted by the coordinator of the consortium funded under HORIZON-HLTH-2024-DISEASE-12-01. No other applicant qualifies.
- Additional partners may be included, but the existing consortium is the only eligible submitter.
- US legal entities are eligible for union funding, provided the concerned consortium of research funders expressly agrees, and subject to restrictions for the protection of European communication networks.
- Award thresholds: 4 for Excellence, 4 for Impact, 4 for Implementation; cumulative threshold of 12.
- If successful, the outcome is a grant agreement amendment, not a new grant.
- Financial support to third parties (FSTP) is allowed in grant form only.
Scientific range: what does the Commission expect from the HORIZON-HLTH-2026-03-DISEASE-13 grant?
What outcomes are expected?
The Commission wants a pan-European clinical research ecosystem ready to mobilize quickly in a health emergency, rather than building from scratch each time one is declared. Besides the clinical network, the Commission wants tangible coordination among research funders, regulators, national authorities, and the scientific community, and evidence-based pandemic preparedness strategies rolled out not only across Europe but, where necessary, globally.
What is within scope?
- The entire range of preparedness research, basic and pre-clinical research, clinical research, public health research, social sciences, and implementation research.
- The role of environmental, ecological, and climatic drivers in the emergence and spread of infectious threats will be discussed within One Health framing research in the partnership.
- Establishment and integration of the always-hot clinical research network, including both observational and interventional studies.
- Coordination with the CT-CM.
- Synergies with the EU4Health Program, the Digital Europe Program, the EU preparedness union strategy, and HERA.
- Joint funding call for transnational and shared data infrastructure.
What are the specifically proposed research directions?
This is a continuation of Phase 1, which is specifically mentioned in the work program; therefore, the research directions are not abstract, but they are the continuation of the already existing SRIA:
- Nurture and sustain the ever-hot clinical research network that is prepared to switch to emergency mode.
- Establish strong, real-time operational coordination with the CT-CM and provide scientific guidance on the clinical research requirements for real responses.
- Integrate and improve data-sharing and knowledge infrastructures at the European level to conduct research on pandemics.
- Ensure that a One Health approach is encouraged and integrated, thereby further defining the origins of pathogens and combining climatic and ecological factors.
- Be aligned with the EU Preparedness Union Strategy (JOIN(2025) 130) and make concrete contributions to the EU Global Health Strategy.
- It is not that the Commission seeks individual scientific findings but research integration, coordination, and readiness.
Scientific strategy: how can you enhance your chances of being funded through HORIZON-HLTH-2026-03-DISEASE-13?
What scientific choices matter most?
- Be more innovative than Phase 1 activities: The BE READY NOW consortium will be known to the evaluators. You need to provide explicit reasons for the new activities and those that will take place beyond Phase 1. So what can be added by introducing a new activity that could not be achieved by the existing partnership alone?
- Bring the idea of the always-hot network to life: What can clinical sites do to sustain their operations and stay in touch with each other during health emergencies? A list of institutions is not enough; evaluators seek governance structure, data sharing, and trigger mechanisms.
- Liaise closely with the CT-CM: The Clinical Trial Coordination Mechanism is mentioned several times in the text; failing to discuss it as an obligatory aspect will have an adverse impact on your score. Document the points of integration.
- It is obligatory to incorporate a One Health approach: We have witnessed projects that do not take into account this and score lowly in the Impact section of the assessment. Statedly identify the connection between your study and climate and ecological risks.
- Neglect not the social sciences and humanities: This has been an invariable aspect of all pandemic preparedness calls, and its absence will certainly be detected by evaluators.
- Develop a strong argument for data infrastructure: Which national or regional data sets will become integrated? Through what type of governance structure? This is not a vague statement but a tangible project deliverable.
Consortium and proposal-writing plan: what works best with this type of call?
It is a COFUND activity that operates in a very different way from other Horizon Europe programs. The consortium is applicable as one entity. Nonetheless, the proposal has a few components that are of importance.
- If you have new partners in Phase 2, their value-add should be clearly stated and justified. Partners who are effectively duplicating competencies will not help build a stronger proposal.
- Include public health agencies and research funding agencies. Member States and Associated Countries: It is essential to ensure broad representation from both in your consortium at Phase 2.
- Ensure geographic diversity. The assessors are also keen on the European coverage of your partnership.
- Incorporate at least one innovative SME in case of incorporation of new partners, particularly those who have diagnostic, data, or platform technologies. It might be important to consider adding 8 or 15 new or increased beneficiaries, maybe even more if the clinical network is extended.
- In terms of writing, keep in mind that your proposal is partly rated against the results of the Phase 1 assessment; you cannot neglect the initial project condition. State clearly what has changed, what lessons have been learned, and how Phase 2 will deal with this, which may actually be more useful than a standard RIA.
- Have your budget section be very succinct. Since it is a 50 percent-funded program, every line item will be subject to scrutiny. FSTP requires a special argumentation.
How would microfluidics contribute to this topic?
Typical methods of pathogen identification rely on centralized labs and involve long waits for results after samples have been sent. The time delay has major implications for pandemic control. Microfluidics reconfigures the basic problem.
- Point-of-care diagnostic devices utilizing microfluidic chips can identify and detect novel pathogens quickly and consistently, thus greatly benefiting distributed clinical trials with many sites across different countries that are performing observational or interventional studies on a range of respiratory pathogens, distinguishing between those of bacterial and viral origin, as well as differentiating between the many novel and known strains.
- Earlier pre-clinical experiments can be facilitated by organ-on-chip models that simulate biological systems, enabling early-stage investigations of pathogen interactions with lung, gut, or blood vessel walls before significant patient cohorts are available for clinical observation. Such early data obtained can directly feed into the network’s observational study component.
- Underrated sample preparation is one area where microfluidic devices shine; they can process saliva, blood, and respiratory fluids in novel ways at scale that conventional techniques cannot replicate. Such standardization of upfront sample processing across a network of 20+ countries can eliminate many sources of variability that might otherwise invalidate comparative analyses.
- The always-hot network paradigm is inherently about rapid deployment; microfluidics is a perfect technology for developing and providing always-hot diagnostic tools that can be adapted for any new pathogen of interest. This is not a hypothetical; in response to COVID-19, existing microfluidic platforms were successfully repurposed faster than the development and rollout of new centralized PCR technologies.
The call is seeking an adaptable, rapid-response research system. Microfluidics presents your consortium with a practical diagnostic and pre-clinical toolkit that aligns perfectly with the readiness goal. MIC’s knowledge of miniaturized detection and organ-on-chip technology can enhance both the preparedness and the One Health components of your proposal.
The MIC already brings its expertise in microfluidics to Horizon Europe:
H2020-NMBP-TR-IND-2020
Microfluidic platform to study the interaction of cancer cells with lymphatic tissue
H2020-LC-GD-2020-3
Toxicology assessment of pharmaceutical products on a placenta-on-chip model
